Somatropin: View Uses, Side Effects and Medicines
Headache, nausea, vomiting, tiredness, muscle pain, or weakness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Read the Patient Information Leaflet and Instructions for Use if available from your pharmacist before you start using this medication and each time you get a refill.
Common side effects of Somatropin
We started in 1995, with growth hormone deficiency (GHD) in children, and we kept innovating from there. Elderly patients may be more likely to have side effects with growth hormone therapy. In children experiencing rapid growth, curvature of the spine may develop or worsen. Patients with scoliosis should be checked regularly to make sure their scoliosis does not get worse during their growth hormone therapy.
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Children should be checked for certain breathing problems (upper airway obstruction) before and during treatment. Heavy snoring or irregular breathing during sleep (sleep apnea) are signs of airway obstruction. Also report any signs of lung infection, such as fever, cough, or trouble breathing. Patients using somatropin may experience decreased blood cortisol levels and/or the masking of central (secondary) adrenal insufficiency if they have or are at risk for pituitary hormone shortages. Following the start of somatropin therapy, patients receiving glucocorticoid replacement therapy for previously identified adrenal insufficiency might need to increase their maintenance or stress dosages.
Table 1Cost Comparison Table for Genotropin for Pediatric Growth Hormone Deficiency
In addition, people with untreated Turner’s syndrome, Noonan’s syndrome, and Prader-Willi syndrome may exhibit skeletal deformities, such as scoliosis. These anomalies, which could appear with growth hormone therapy, should be known to clinicians. If sleep apnea is suspected in any Prader-Willi syndrome patient, that patient should also be watched. Additionally, cerebral hypertension may be more common in Prader-Willi syndrome patients. Endogenous growth hormone is responsible for stimulating normal skeletal, connective tissue, muscle, and organ growth in children and adolescents.
What is Norditropin® (somatropin) injection?
Children who experience growth failure due to renal impairment should also be examined for the development of renal osteodystrophy. The safety of continuing somatropin therapy in patients receiving replacement doses for situations for which the medication has been approved has not been established. Therefore, in patients with acute critical conditions, the potential benefit of continued somatropin therapy should be weighed against the potential risk.
Your Child Is Much More Than Feet and Inches
Do not use more of this medication than prescribed or use it more often since the risk of side effects will be increased. You are encouraged to report negative side effects of prescription drugs to the FDA. Weight-based doses use an average weight of 38.32 kg as reported in Takeda et al.1 for pediatric patients with GHD who were between ages 9 and 16. Assumes daily doses and wastage of excess for single-dose syringes. In neonates and patients who have benzyl alcohol hypersensitivity, several multi-dose somatropin preparations that contain benzyl alcohol should be used with caution.
Side Effects
Consider the hazards and advantages of initiating somatropin in patients who have certain rare genetic causes of low stature since they have an elevated chance of developing cancer. Patients with neoplastic disease that is active should not take somatropin. Children’s response to somatropin medication tends to decline over time. A clinician should examine any child using somatropin who complains of hip or knee pain or who develops a limp. Patients with endocrine disorders or growing children may experience slipped capital femoral epiphysis more commonly.
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Learn about different growth-related disorders, including growth hormone deficiency, Turner syndrome, and more. Patients treated with growth hormone should be checked regularly for low serum cortisol levels and/or somatropin injection price the need to increase the dose of the glucocorticoids they are taking. Growth hormone should not be used in patients who have been recently diagnosed with cancer, with cancer, or who are being treated for cancer.
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Somatropin is also not recommended for use in children with Prader-Willi syndrome and respiratory insufficiency due to cases of mortality (see Prader-Willi discussion). Norditropin® (somatropin) injection is indicated for use in children with growth failure or short stature due to certain growth-related disorders and adults with growth hormone deficiency. Somatropin products are contraindicated in patients with a known hypersensitivity to somatropin or any of the product excipients. Serious systemic hypersensitivity reactions including anaphylactic reactions and angioedema have been reported with post-marketing use of somatropin products. Several of the products contain m-cresol as a preservative. Some of the formulations recommend using sterile water for injection as a diluent in patients with m-cresol hypersensitivity; other products recommend using other formulations.
- In childhood cancer survivors, treatment with growth hormone may increase the risk of a new tumor, particularly certain benign brain tumors.
- Growth hormone should not be used in patients with diabetes who have certain types of diabetic retinopathy (eye problems).
- Serious systemic hypersensitivity reactions including anaphylactic reactions and angioedema have been reported with post-marketing use of somatropin products.
- Patients treated with growth hormone should be checked regularly for low serum cortisol levels and/or the need to increase the dose of the glucocorticoids they are taking.
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- This can help to prevent skin problems such as lumpiness or soreness.
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- Children should be checked for certain breathing problems (upper airway obstruction) before and during treatment.
What are the possible side effects of Sogroya®?
Some patients have developed diabetes mellitus while taking GENOTROPIN. Dosage of diabetes medicines may need to be adjusted during growth hormone treatment. Patients should be watched carefully if growth hormone is given along with glucocorticoid therapy and/or other drugs that are processed by the body in the same way. If necessary, your child’s doctor may prescribe GENOTROPIN, which is a growth hormone therapy for children and adults with certain growth disorders. GENOTROPIN is a prescription product for the replacement of growth hormone in adults with growth hormone deficiency (GHD) that started either in childhood or as an adult. Your doctor should do tests to be sure you have GHD, as appropriate.
Do not use medications containing lonapegsomatropin while using somatropin. If you are using a pen device, do not share your pen device with another person, even if the needle is changed. You may give other people a serious infection, or get a serious infection from them.
Somatropin binds to growth hormone (GH) receptors and produces a variety of physiologic effects that can be classified as being direct or indirect. These effects oppose the action of insulin on fat and carbohydrate metabolism and are potentiated by glucocorticoids. In studies of GENOTROPIN in children with Turner syndrome, side effects included flu, throat, ear, or sinus infection, runny nose, joint pain, and urinary tract infection. Information provided on this Web site is neither intended nor implied to be a substitute for professional medical advice. You should not use this information on this web site or the information on links from this site to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. And Norditropin® is approved for more of them than any other treatment.
Freedom from daily injections with once-weekly Sogroya®, the first and only once-weekly growth hormone (GH) treatment for both children and adults with growth hormone deficiency (GHD). It has been shown that somatropin medication can result in elevated intracranial pressure, papilledema, visual abnormalities, headaches, nausea, and/or vomiting. Within the first eight weeks of somatropin medication, symptoms often started to appear. The symptoms of intracranial hypertension went away either when somatropin medication was stopped or after the hormone’s dosage was decreased. When starting somatropin therapy and at intervals thereafter, funduscopic examination is advised. Patients with Prader-Willi syndrome, Turner’s syndrome, and chronic renal insufficiency may be more likely to develop intracranial hypertension.
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In addition, people with endocrine abnormalities or those going through rapid growth may experience slipping capital femoral epiphysis more frequently. Some laboratory results may vary as a result of somatropin medication. With somatropin medication, serum levels of inorganic phosphorus, alkaline phosphatase, and parathyroid hormone may rise.
It has not been determined if it is safe to continue somatropin therapy in individuals getting replacement dosages for medical conditions for which the drug has been licensed. Therefore, the possible benefit of continuing somatropin medication should be balanced against the potential risk in patients with acute critical diseases. Additionally, because there have been instances of fatalities, somatropin is not advised for usage in children with Prader-Willi syndrome and respiratory insufficiency (see Prader-Willi discussion). Meningiomas, in particular, were the most prevalent of these second neoplasms, which included intracranial tumors. It is unclear if adult CNS tumor recurrence and somatropin replacement therapy are related in any way. While receiving somatropin therapy, all patients who have a history of growth hormone deficiency as a result of an intracranial neoplasm should be routinely checked for tumor development or recurrence.
So, the presence of these brain tumors should be ruled out before treatment is started. Growth hormone should not be used if it is shown that a previous brain tumor has come back or is getting larger. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). If this medicine is used for weight loss/muscle wasting, it may take up to 2 weeks to notice the effects of the drug.
You may report side effects to FDA at FDA-1088 or at /medwatch. Inject this medication under the skin as directed by your doctor. The dosage is based on your age, weight, medical condition and response to treatment. Use a different place on the body each day for growth hormone injections. This can help to prevent skin problems such as lumpiness or soreness.
When this medication is given to newborns, mix with sterile water for injection that does not contain a preservative. The risk is greater with lower birth weight infants and is greater with increased amounts of benzyl alcohol. Symptoms include sudden gasping, low blood pressure, or a very slow heartbeat.
- Consult the product instructions and your pharmacist for storage details.
- Patients with diabetes should utilize somatropin with caution.
- It has been shown that somatropin medication can result in elevated intracranial pressure, papilledema, visual abnormalities, headaches, nausea, and/or vomiting.
- Therefore, in patients with acute critical conditions, the potential benefit of continued somatropin therapy should be weighed against the potential risk.
- Thyroid function should be checked regularly during growth hormone therapy.
- IGF-1 is directly responsible for chondrogenesis, skeletal growth, and the growth of soft tissue.
- Many people using this medication do not have serious side effects.
Thyroid function should be checked regularly during growth hormone therapy. Thyroid hormone replacement therapy should be started or adjusted if needed. Lab and/or medical tests (such as eye exams, thyroid function, glucose levels, growth hormone antibody levels) will be done while you are using this medication.
The principal anabolic actions of IGFs include stimulation of amino acid transport, stimulation of DNA, RNA, and protein synthesis, and induction of cell proliferation and growth. IGF-1 is directly responsible for chondrogenesis, skeletal growth, and the growth of soft tissue. Linear growth is stimulated by affecting cartilaginous growth areas of long bones. Growth is also stimulated by increasing the number and size of skeletal muscle cells, influencing the size of organs, and increasing red cell mass through erythropoietin stimulation. The actions of growth hormone on the gut may be direct or mediated via the local or systemic production of IGF. In-vivo studies have shown that growth hormone enhances transmucosal transport of water, electrolytes, and nutrients.
Growth hormone should only be used during pregnancy if clearly needed. It should be used with caution in nursing mothers because it is not known whether growth hormone is passed into human milk. Consult the product instructions and your pharmacist for storage details. It is important to get each dose of this medication as scheduled. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule.
- Properly discard this product when it is expired or no longer needed.
- Thyroid hormone replacement therapy should be started or adjusted if needed.
- Throw away any unused medicine after the beyond use date.
- All products displayed on Tata 1mg are procured from verified and licensed pharmacies.
- A health care provider will help you with the first injection.
- If you notice other effects not listed above, contact your doctor or pharmacist.
- Sogroya® is given by injection under the skin and is used to treat adults and children 2.5 years and older who do not make enough growth hormone.
If you have diabetes, this drug may increase your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. Your doctor may need to adjust your diabetes medication, exercise program, or diet.
Due to supply disruptions in the growth hormone market, the Pfizer Bridge Program is experiencing very high call volumes and increased demand for Genotropin pen devices. Long hold times are possible on the phone and patients may have to wait to receive a Genotropin pen. Pfizer does not foresee any long-term supply disruption and we are working to resolve the situation as quickly as possible.
Turner syndrome patients taking growth hormone therapy may be more likely to get ear infections. In studies of GENOTROPIN in children with PWS, side effects included fluid retention, aggressiveness, joint and muscle pain, hair loss, headache, and increased pressure in the brain. In studies of GENOTROPIN in adults with GHD, side effects included fluid retention, joint or muscle pain, stiffness, and changes in sensation. Usually these side effects did not last long and depended on the dose of GENOTROPIN being taken.
Ask your health care professional how to prepare and use this medication. If you have any questions, ask your doctor or pharmacist. You should check with your physician/health care provider before using any of the means or methods presented on this site.
If this medicine is used for short bowel syndrome, consult your doctor if a special diet (high carbohydrate/low-fat) or the use of nutritional supplements may be helpful. Before using, check this product for particles or discoloration. Before injecting each dose, clean the skin you are going to inject into (the injection site) with rubbing alcohol.
Patients with diabetes should utilize somatropin with caution. During somatropin therapy, patients with diabetes or glucose intolerance, as well as those who have risk factors for developing these conditions, should be continuously watched. Obesity (including obesity in Prader-Willi syndrome individuals), Turner syndrome, or a family history of type II diabetes are risk factors for glucose intolerance. Deaths have been reported with the use of growth hormone in children with Prader-Willi syndrome. These children were extremely overweight, had breathing problems, and/or lung infection. All patients with Prader-Willi syndrome should be examined for these problems.
Report these symptoms to the doctor right away should they occur. In children experiencing rapid growth, limping or hip or knee pain may occur. If a child getting growth hormone therapy starts to limp or gets hip or knee pain, the child’s doctor should be notified and the child should be examined. A small number of patients treated with growth hormone have had increased pressure in the brain. Treatment should be stopped and reassessed in these patients. Patients with Turner syndrome and Prader-Willi syndrome may be at higher risk of developing increased pressure in the brain.
The products discussed in this site may have different product labeling in different countries. The information provided is for educational purposes only and is not intended to replace discussions with a healthcare provider. Older adults may be more sensitive to the side effects of this drug, especially effects on blood sugar, or swelling ankles/feet. Somatropin may increase your risk of getting a tumor or cancer. Discuss the details and the risks and benefits of this medication with your doctor.
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